Molecular dynamic simulation study of cholesterol and conjugated double bonds in lipid bilayers
نویسندگان
چکیده
منابع مشابه
Conjugated double bonds in lipid bilayers: a molecular dynamics simulation study.
Conjugated linoleic acids (CLA) are found naturally in dairy products. Two isomers of CLA, that differ only in the location of cis and trans double bonds, are found to have distinct and different biological effects. The cis 9 trans 11 (C9T11) isomer is attributed to have the anti-carcinogenic effects, while the trans 10 cis 12 (T10C12) isomer is believed to be responsible for the anti-obesity e...
متن کاملCholesterol perturbs lipid bilayers nonuniversally.
Cholesterol is well known to modulate the physical properties of biomembranes. Using modern x-ray scattering methods, we have studied the effects of cholesterol on the bending modulus K(C), the thickness D(HH), and the orientational order parameter S(xray) of lipid bilayers. We find that the effects are different for at least three classes of phospholipids characterized by different numbers of ...
متن کاملHigh-temperature molecular dynamics simulation of lipid membrane bilayers
9 10 In this work we investigated the molecular dynamics of palmitoyl-oleoyl-phosphatidylcholine 11 and palmitoyl-oleoyl-phosphatidylethanolamine membrane bilayers enforced by single-wall 12 carbon nanotube using classical molecular dynamics simulation. We have considered that an 13 insertion of a single-wall carbon nanotube in the center of lipid membrane “strengthens” ambient 14 lipids and pr...
متن کاملMolecular dynamics simulation of polymer insertion into lipid bilayers
Relatively short peptides, such as toxins and antimicrobial-peptides, are known to insert themselves into cell membranes. On the basis of simple bead-spring models for the membrane lipids, the peptide, and water, detailed processes of the peptide insertion is investigated by molecular dynamics simulation; our special concern is in the highly cooperative motions of membrane lipids and the peptid...
متن کاملStructural properties of archaeal lipid bilayers: small-angle X-ray scattering and molecular dynamics simulation study.
Aeropyrum pernix is an aerobic hyperthermophilic archaeon that grows in harsh environmental conditions and as such possesses unique structural and metabolic features. Its membrane interfaces with the extreme environment and is the first line of defense from external factors. Therefore, lipids composing this membrane have special moieties that increase its stability. The membrane of A. pernix is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemistry and Physics of Lipids
سال: 2011
ISSN: 0009-3084
DOI: 10.1016/j.chemphyslip.2011.09.008